Association between LIN28B gene polymorphisms and Wilms' tumor susceptibility

Biomark Med. 2022 Oct;16(15):1113-1120. doi: 10.2217/bmm-2022-0291. Epub 2023 Jan 6.


Aim: To survey the association between LIN28B gene polymorphisms and the increased risk of Wilms' tumor (WT). Methods: Five LIN28B polymorphisms (rs314276 C>A, rs221634 A>T, rs221635 T>C, the rs4145418 A>C and rs9404590 T>G) were genotyped in 355 WT patients and 1070 healthy controls to assess the association. Result: The rs314276 CA/AA genotype was a protective factor against WT (corrected odds ratio [OR]: 0.71; p = 0.006). Individuals older than 18 months (corrected OR: 0.60; p = 0.001), males (corrected OR: 0.65; p = 0.011) and in clinical stage I + II patients (corrected OR: 0.60; p = 0.0008) with this genotype were less susceptible to WT. Conclusion: The rs314276 CA/AA genotype may protect against WT.

Keywords: LIN28B; Wilms' tumor; multicenter study; polymorphism; rs221634 A>T; rs221635 T>C; rs314276 C>A; rs4145418 A>C; rs9404590 T>G; susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Kidney Neoplasms* / genetics
  • Male
  • Polymorphism, Single Nucleotide
  • RNA-Binding Proteins / genetics
  • Wilms Tumor* / genetics


  • LIN28B protein, human
  • RNA-Binding Proteins