Comparison of cord blood pro-BNP levels in newborns of SARS-COV-2-positive and -negative women, and its association with adverse perinatal outcomes

Int J Gynaecol Obstet. 2023 Apr;161(1):308-313. doi: 10.1002/ijgo.14655. Epub 2023 Jan 18.


Objective: To compare umbilical cord blood pro-B-type natriuretic peptide (BNP) levels in newborns of severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) positive pregnancies to those of SARS-COV-2 negative pregnancies.

Methods: Prospectively cord blood samples from newborns of 42 SARS-COV-2 positive women, and 42 negative pregnant were collected at birth and analyzed for pro-BNP levels.

Results: The mean cord blood pro-BNP level was significantly higher in newborns of SARS-COV-2 positive women than in controls. Furthermore, the pro-BNP level was an independent predictor of NİCU admission in both SARS-COV-2 positive and control patients.

Conclusion: Cord blood pro-BNP level may be a parameter that can predict the under-stress fetus and adverse perinatal outcomes especially, in cases where placental involvement is present as in SARS-COV-2 infection.

Keywords: NICU prediction; cord pro-BNP; maternal SARS-COV-2 positivity.

Publication types

  • Comparative Study

MeSH terms

  • COVID-19*
  • Female
  • Fetal Blood
  • Humans
  • Infant, Newborn
  • Infectious Disease Transmission, Vertical
  • Natriuretic Peptide, Brain
  • Placenta
  • Pregnancy
  • Pregnancy Complications, Infectious* / epidemiology
  • SARS-CoV-2


  • Natriuretic Peptide, Brain