Targeting RNA Splicing Overcomes Leukemia Resistance to BCL2 Inhibition

Cancer Discov. 2023 Mar 1;13(3):OF3. doi: 10.1158/2159-8290.CD-RW2023-003.

Abstract

Inactivation of RNA splicing factors enhances BCL2 inhibition in acute myeloid leukemia (AML).

MeSH terms

  • Apoptosis
  • Humans
  • Leukemia, Myeloid, Acute* / drug therapy
  • Leukemia, Myeloid, Acute* / genetics
  • Proto-Oncogene Proteins c-bcl-2* / genetics
  • Proto-Oncogene Proteins c-bcl-2* / metabolism
  • RNA Splicing

Substances

  • Proto-Oncogene Proteins c-bcl-2
  • BCL2 protein, human