Recent trends in food protein-induced enterocolitis syndrome (FPIES)

Mary Grace Baker; Hugh A Sampson

doi:10.1016/j.jaci.2022.11.002

Recent trends in food protein-induced enterocolitis syndrome (FPIES)

J Allergy Clin Immunol. 2023 Jan;151(1):43-46. doi: 10.1016/j.jaci.2022.11.002.

Authors

Mary Grace Baker¹, Hugh A Sampson²

Affiliations

¹ Elliot and Roslyn Jaffe Food Allergy Institute, Division of Pediatric Allergy & Immunology, Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: marygrace.baker@mssm.edu.
² Elliot and Roslyn Jaffe Food Allergy Institute, Division of Pediatric Allergy & Immunology, Kravis Children's Hospital, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 36608982
DOI: 10.1016/j.jaci.2022.11.002

Abstract

Food protein-induced enterocolitis syndrome (FPIES) was first described in detail in the late 20th century as a non-IgE-mediated food allergy characterized by delayed gastrointestinal symptoms after ingestion of a trigger food. Although the initial case series reported infants reacting to cow's milk- and soy-based formulas, we now recognize that FPIES affects patients across the age spectrum. This brief review highlights our evolving understanding of FPIES with a discussion of triggers, epidemiology, food challenges, and pathophysiology.

Keywords: Food protein–induced enterocolitis syndrome; food allergy; food hypersensitivity; food intolerance.

Publication types

Review
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Allergens
Animals
Cattle
Dietary Proteins / adverse effects
Enterocolitis* / epidemiology
Female
Food Hypersensitivity* / epidemiology
Milk
Syndrome

Substances

Allergens
Dietary Proteins