Nano-delivery systems for encapsulation of phenolic compounds from pomegranate peel

Adv Colloid Interface Sci. 2023 Jan:311:102833. doi: 10.1016/j.cis.2022.102833. Epub 2023 Jan 2.


Pomegranate fruit is getting more attention due to its positive health effects, and pomegranate peel (PP) is its main byproduct. PP has the potential to be converted from environmentally polluting waste to wealth due to its rich phenolic compounds such as ellagitannins, proanthocyanidins, and flavonoids with antioxidant, antimicrobial, and health effects. These phenolics are susceptible to environmental conditions such as heat, light, and pH as well as in vivo conditions of gastrointestinal secretions. Some phenolics of PP, e.g., ellagitannins could interfere with food ingredients and thus reduce their beneficial effects. Also, ellagitannins could form complexes with salivary glycoproteins, then a feeling of astringency taste. In this article, nano-delivery systems such as nanoparticles, nanoemulsions, and vesicular nanocarriers, designed and fabricated for PP bioactive compounds in recent years have been reviewed. Among them, lipid-based nano carriers i.e., solid lipid nanoparticles, nanostructured lipid carriers, and vesicular nanocarriers have low toxicity, large-scale production feasibility, easy synthesis, and high biocompatibility. So, it seems that the extraction and purification of bioactives from pomegranate wastes and nanoencapsulating them with cost effective and generally recognized as safe (GRAS) materials can be a bright prospect in enhancing the quality, safety, shelf life and health benefits of pomegranate products.

Keywords: Encapsulation; Health effects; Phenolic compounds; Pomegranate; Supplements.

Publication types

  • Review

MeSH terms

  • Antioxidants / chemistry
  • Antioxidants / pharmacology
  • Fruit* / chemistry
  • Hydrolyzable Tannins / analysis
  • Lipids / analysis
  • Nanoparticle Drug Delivery System
  • Phenols
  • Plant Extracts / chemistry
  • Pomegranate* / chemistry


  • Hydrolyzable Tannins
  • Nanoparticle Drug Delivery System
  • Plant Extracts
  • Phenols
  • Antioxidants
  • Lipids