One Health: Animal Models of Heritable Human Bleeding Diseases

Animals (Basel). 2022 Dec 26;13(1):87. doi: 10.3390/ani13010087.


Animal models of human and animal diseases have long been used as the lynchpin of experimental and clinical research. With the discovery and implementation of novel molecular and nano-technologies, cellular research now has advanced to assessing signal transduction pathways, gene editing, and gene therapies. The contribution of heritable animal models to human and animal health as related to hemostasis is reviewed and updated with the advent of gene editing, recombinant and gene therapies.

Keywords: animal models; hemostasis; heritable bleeding disorders; human disease.

Publication types

  • Review

Grants and funding

This author and her colleagues have been privileged to have received federal research funding to study the inherited and acquired bleeding disorders of humans and animals for more than 5 decades, NIH NHLBI Grant HL09902. This information was shared globally in person and in print with other human and comparative medicine colleagues.