Xylityl Sesquicaprylate Efficacy as an Antiseptic Ingredient for Oral Care Products (Mouthwash): An In Vitro Screening Investigation against Eight Microorganisms

Molecules. 2022 Dec 21;28(1):28. doi: 10.3390/molecules28010028.


For dental caries and periodontal diseases initiated by dental plaque (as bacterial communities) and to inhibit the growth of oral pathogenic bacteria, oral care products containing antiseptic active ingredients are highly recommended, nonetheless, side effects of such actives are a concern (teeth discoloration/staining and taste perception, for example). In this context, we challenged xylityl sesquicaprylate, an antiseptic compound from natural resources, as an active ingredient to be used in an alcohol-free mouthwash formulation. The xylityl sesquicaprylate sample was compared to a respective blank mouthwash formulation and one containing triclosan. The in vitro efficacy was screened by the time-kill assay against eight microorganisms. The xylityl sesquicaprylate-containing mouthwash (0.45% w/w) presented a particularly interesting profile of efficacy against Actinomyces viscosus, Fusobacterium nucleatum, Porphyromonas gingivalis, and Tannerella forsythia, with results of greater magnitude to reduce the log10 of those microorganisms in comparison with the triclosan sample.

Keywords: alcohol-free mouthwash; time-kill test; triclosan; xylityl sesquicaprylate.

MeSH terms

  • Anti-Infective Agents, Local* / pharmacology
  • Dental Caries* / drug therapy
  • Humans
  • Mouthwashes / pharmacology
  • Porphyromonas gingivalis
  • Triclosan* / pharmacology


  • Anti-Infective Agents, Local
  • Mouthwashes
  • Triclosan