Advances in the Synthesis of Fused 1,2,3-Triazoles via a MCR-Intramolecular Azide-Alkyne Cycloaddition Approach

Molecules. 2022 Dec 30;28(1):308. doi: 10.3390/molecules28010308.


The present review narrates several reports which deal with the synthesis of fused 1,2,3-triazole containing scaffolds following a sequential multicomponent reaction (MCR)-intramolecular azide-alkyne cycloaddition (IAAC) approach. The reviewed reactions were cleverly designed so as to incorporate azide and alkyne functionalities in the MCR product which was then subjected to IAAC. The review is divided into two sections based on the number of components in the multicomponent reaction. We have aimed at a critical discussion and also have highlighted either advantages or disadvantages of each methodology.

Keywords: 1,2,3-triazole; dipolar cycloaddition; intramolecular azide-alkyne cycloaddition; multicomponent reaction.

Publication types

  • Review

MeSH terms

  • Alkynes*
  • Azides*
  • Catalysis
  • Cycloaddition Reaction
  • Molecular Structure
  • Triazoles


  • Azides
  • Alkynes
  • Triazoles