Electricity-Wettability Controlled Fast Transmission of Dopamine in Nanochannels

Small. 2023 Apr;19(15):e2205488. doi: 10.1002/smll.202205488. Epub 2023 Jan 8.


Achieving fast transmembrane transmission of molecules in organisms is a challenging problem. Inspired by the transport of Dopmine (DA) in organisms, the DA transporter (DAT) binds to DA in a way that has a ring recognition (the recognition group is the tryptophan group). Herein, D-Tryptophan-pillar[5]arene (D-Trp-P5) functionalized conical nanochannel is constructed to achieve fast transmission of DA. The D-Trp-P5 functionalized nanochannel enables specific wettability recognition of DA molecules and has great cycle stability. With the controlling of voltage to wettability, the transport flux of DA is up to 499.73 nmol cm-2 h-1 at -6 V, 16.88 times higher than that under positive voltages. In response to these results, a high-throughput DA transport device based on controlled electricity-wettability is provided.

Keywords: dopamine; electricity-wettability; nanochannels; pillar[n]arene.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Dopamine*
  • Electricity
  • Tryptophan*
  • Wettability


  • Dopamine
  • Tryptophan