Case report: A report of the complete pathological response of intrahepatic cholangiocarcinoma after conversion therapy

Front Immunol. 2022 Dec 23:13:1051130. doi: 10.3389/fimmu.2022.1051130. eCollection 2022.

Abstract

Cholangiocarcinoma (CCA) is a rare disease with poor prognosis, and surgery remains the only curative treatment option. However, surgery is inappropriate for the majority of patients with CCA. Conversion therapy may provide opportunities for the surgical treatment of these patients. Herein, we describe a patient with intrahepatic CCA who was first treated with albumin-bound paclitaxel, cisplatin, and gemcitabine in combination with camrelizumab. The patient then successfully underwent surgery and achieved pathological complete remission. This report can serve as a reference for clinicians regarding conversion therapy for intrahepatic CCA.

Keywords: albumin paclitaxel; carrelizumab; case report; cholangiocarcinoma; cisplatin; conversion therapy; gemcitabine.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Bile Duct Neoplasms* / drug therapy
  • Bile Duct Neoplasms* / pathology
  • Bile Ducts, Intrahepatic / pathology
  • Cholangiocarcinoma* / drug therapy
  • Cholangiocarcinoma* / pathology
  • Deoxycytidine / therapeutic use
  • Gemcitabine
  • Humans

Substances

  • Deoxycytidine
  • Gemcitabine