The role of NLRP3 inflammasome in digestive system malignancy

Cen-Cen Sun; Li Li; Hou-Quan Tao; Zhi-Chen Jiang; Liang Wang; Hui-Ju Wang

doi:10.3389/fcell.2022.1051612

The role of NLRP3 inflammasome in digestive system malignancy

Front Cell Dev Biol. 2022 Dec 23:10:1051612. doi: 10.3389/fcell.2022.1051612. eCollection 2022.

Authors

Cen-Cen Sun¹, Li Li^{2

3}, Hou-Quan Tao^{2

3}, Zhi-Chen Jiang², Liang Wang⁴, Hui-Ju Wang^{2

3}

Affiliations

¹ Basic Medical Experimental Teaching Center, Zhejiang University, Hangzhou, China.
² Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
³ Cancer Center, General Surgery, Department of Gastrointestinal and Pancreatic Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.
⁴ Center for Plastic and Reconstructive Surgery, Department of Hand and Reconstruction Surgery, Zhejiang Provincial People's Hospital, Affiliated People's Hospital, Hangzhou Medical College, Hangzhou, China.

Abstract

Digestive system malignancies, the most common types of cancer and a major cause of death in the worldwide, are generally characterized by high morbidity, insidious symptoms and poor prognosis. NLRP3 inflammasome, the most studied inflammasome member, is considered to be crucial in tumorigenesis. In this paper, we reviewed its pro-tumorigenic and anti-tumorigenic properties in different types of digestive system malignancy depending on the types of cells, tissues and organs involved, which would provide promising avenue for exploring new anti-cancer therapies.

Keywords: NLRP3; anti-tumorigenic; digestive system malignancy; inflammasome; pro-tumorigenic.

Publication types

Review