Liver injury in COVID-19: A minireview

World J Gastroenterol. 2022 Dec 21;28(47):6716-6731. doi: 10.3748/wjg.v28.i47.6716.


Coronavirus disease 2019 (COVID-19), caused by infection with the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), has escalated into a global tragedy afflicting human health, life, and social governance. Through the increasing depth of research and a better understanding of this disease, it has been ascertained that, in addition to the lungs, SARS-CoV-2 can also induce injuries to other organs including the liver. Liver injury is a common clinical manifestation of COVID-19, particularly in severe cases, and is often associated with a poorer prognosis and higher severity of COVID-19. This review focuses on the general existing information on liver injury caused by COVID-19, including risk factors and subpopulations of liver injury in COVID-19, the association between preexisting liver diseases and the severity of COVID-19, and the potential mechanisms by which SARS-CoV-2 affects the liver. This review may provide some useful information for the development of therapeutic and preventive strategies for COVID-19-associated liver injury.

Keywords: Angiotensin-converting enzyme 2; Chronic liver disease; Liver; SARS-CoV-2; Transmembrane serine protease 2.

Publication types

  • Review

MeSH terms

  • COVID-19* / complications
  • Humans
  • Liver
  • Peptidyl-Dipeptidase A
  • Risk Factors
  • SARS-CoV-2


  • Peptidyl-Dipeptidase A