RIFM fragrance ingredient safety assessment, 2,6-dimethylpyrazine, CAS registry number 108-50-9

A M Api; D Belsito; D Botelho; M Bruze; G A Burton Jr; M A Cancellieri; H Chon; M L Dagli; W Dekant; C Deodhar; A D Fryer; L Jones; K Joshi; M Kumar; A Lapczynski; M Lavelle; I Lee; D C Liebler; H Moustakas; M Na; T M Penning; G Ritacco; J Romine; N Sadekar; T W Schultz; D Selechnik; F Siddiqi; I G Sipes; G Sullivan; Y Thakkar; Y Tokura

doi:10.1016/j.fct.2023.113600

RIFM fragrance ingredient safety assessment, 2,6-dimethylpyrazine, CAS registry number 108-50-9

Food Chem Toxicol. 2023 Mar:173 Suppl 1:113600. doi: 10.1016/j.fct.2023.113600. Epub 2023 Jan 6.

Authors

A M Api¹, D Belsito², D Botelho¹, M Bruze³, G A Burton Jr⁴, M A Cancellieri¹, H Chon¹, M L Dagli⁵, W Dekant⁶, C Deodhar¹, A D Fryer⁷, L Jones¹, K Joshi¹, M Kumar¹, A Lapczynski¹, M Lavelle¹, I Lee¹, D C Liebler⁸, H Moustakas¹, M Na¹, T M Penning⁹, G Ritacco¹, J Romine¹, N Sadekar¹, T W Schultz¹⁰, D Selechnik¹, F Siddiqi¹, I G Sipes¹¹, G Sullivan¹², Y Thakkar¹, Y Tokura¹³

Affiliations

¹ Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA.
² Member Expert Panel for Fragrance Safety, Columbia University Medical Center, Department of Dermatology, 161 Fort Washington Ave., New York, NY, 10032, USA.
³ Member Expert Panel for Fragrance Safety, Malmo University Hospital, Department of Occupational & Environmental Dermatology, Sodra Forstadsgatan 101, Entrance 47, Malmo, SE-20502, Sweden.
⁴ Member Expert Panel for Fragrance Safety, School of Natural Resources & Environment, University of Michigan, Dana Building G110, 440 Church St., Ann Arbor, MI, 58109, USA.
⁵ Member Expert Panel for Fragrance Safety, University of Sao Paulo, School of Veterinary Medicine and Animal Science, Department of Pathology, Av. Prof. dr. Orlando Marques de Paiva, 87, Sao Paulo, CEP, 05508-900, Brazil.
⁶ Member Expert Panel for Fragrance Safety, University of Wuerzburg, Department of Toxicology, Versbacher Str. 9, 97078 Würzburg, Germany.
⁷ Member Expert Panel for Fragrance Safety, Oregon Health & Science University, 3181 SW Sam Jackson Park Rd., Portland, OR, 97239, USA.
⁸ Member Expert Panel for Fragrance Safety, Vanderbilt University School of Medicine, Department of Biochemistry, Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN, 37232-0146, USA.
⁹ Member of Expert Panel for Fragrance Safety, University of Pennsylvania, Perelman School of Medicine, Center of Excellence in Environmental Toxicology, 1316 Biomedical Research Building (BRB) II/III, 421 Curie Boulevard, Philadelphia, PA, 19104-3083, USA.
¹⁰ Member Expert Panel for Fragrance Safety, The University of Tennessee, College of Veterinary Medicine, Department of Comparative Medicine, 2407 River Dr., Knoxville, TN, 37996- 4500, USA.
¹¹ Member Expert Panel for Fragrance Safety, Department of Pharmacology, University of Arizona, College of Medicine, 1501 North Campbell Avenue, P.O. Box 245050, Tucson, AZ, 85724-5050, USA.
¹² Research Institute for Fragrance Materials, Inc., 50 Tice Boulevard, Woodcliff Lake, NJ, 07677, USA. Electronic address: gsullivan@rifm.org.
¹³ Member Expert Panel for Fragrance Safety, The Journal of Dermatological Science (JDS), Editor-in-Chief, Professor and Chairman, Department of Dermatology, Hamamatsu University School of Medicine, 1-20-1 Handayama, Higashi-ku, Hamamatsu, 431-3192, Japan.

PMID: 36621670
DOI: 10.1016/j.fct.2023.113600

No abstract available

MeSH terms

Odorants*

Substances

2,5-dimethylpyrazine