Suicide left ventricle following protamine: A case report

Catheter Cardiovasc Interv. 2023 Feb;101(3):592-595. doi: 10.1002/ccd.30528. Epub 2023 Jan 10.


A patient with severe aortic stenosis and left ventricular hypertrophy underwent a transcatheter aortic valve replacement. The patient's blood pressure significantly dropped after protamine administration. A diagnosis of suicide left ventricle post-valve replacement was made. The diagnosis and management of the protamine reaction are detailed. This case highlights the need to slowly infuse protamine sulfate and monitor for adverse events.

Keywords: aortic valve; complication; heart failure; left ventricle function; valve replacement.

Publication types

  • Case Reports

MeSH terms

  • Aortic Valve / diagnostic imaging
  • Aortic Valve / surgery
  • Aortic Valve Stenosis* / diagnostic imaging
  • Aortic Valve Stenosis* / surgery
  • Heart Ventricles
  • Humans
  • Hypertrophy, Left Ventricular
  • Transcatheter Aortic Valve Replacement* / adverse effects
  • Treatment Outcome