Immune cells regulate matrix metalloproteinases to reshape the tumor microenvironment to affect the invasion, migration, and metastasis of pancreatic cancer

Chunqiu Wang; Zhen Deng; Longjun Zang; Yufeng Shu; Suifang He; Xin Wu

Immune cells regulate matrix metalloproteinases to reshape the tumor microenvironment to affect the invasion, migration, and metastasis of pancreatic cancer

Am J Transl Res. 2022 Dec 15;14(12):8437-8456. eCollection 2022.

Authors

Chunqiu Wang¹, Zhen Deng², Longjun Zang³, Yufeng Shu⁴, Suifang He⁵, Xin Wu⁶

Affiliations

¹ Department of Gastroenterology, The Qinghai Provincial People's Hospital Xining 810007, Qinghai, China.
² Department of Hepatopancreatobiliary Surgery, The Third Xiangya Hospital, Central South University Changsha 410013, Hunan, China.
³ Department of General Surgery, Taiyuan Central Hospital Taiyuan 030000, Shanxi, China.
⁴ Department of Gastroenterology, The Third Xiangya Hospital, Central South University Changsha 410013, Hunan, China.
⁵ Department of Plastic and Reconstructive Surgery, The Third Xiangya Hospital, Central South University Changsha 410013, Hunan, China.
⁶ Department of Spine Surgery, The Third Xiangya Hospital, Central South University Changsha 410013, Hunan, China.

PMID: 36628243
PMCID: PMC9827340

Abstract

This study aimed to identify author, country, institutional, and journal collaborations and assess their impact, along with knowledge base, as well as identify existing trends, and uncover emerging topics related to matrix metalloproteinase and pancreatic-cancer research. A total of 1474 Articles and reviews were obtained from the Web of Science Core Collection and analyzed by Citespace and Vosviewer. CANCER RESEARCH, CLINICAL CANCER RESEARCH, and FRONTIERS IN IMMUNOLOGY are the most influential journals. The three main aspects of research in matrix metalloproteinases-pancreatic cancer-related fields included the pathogenesis mechanism of pancreatic cancer, how matrix metalloproteinases affect the metastasis of pancreatic cancer, and what role matrix metalloproteinases play in pancreatic cancer treatment. Tumor microenvironment, pancreatic stellate cells, drug resistance, and immune cells have recently emerged as research hot spots. In the future, exploring how immune cells affect matrix metalloproteinases and reshape the tumor microenvironment may be the key to curing pancreatic cancer. This study thus offers a comprehensive overview of the matrix metalloproteinases-pancreatic cancer-related field using bibliometrics and visual methods, providing a valuable reference for researchers interested in matrix metalloproteinases-pancreatic cancer.

Keywords: Matrix metalloproteinases; immune cells; invasion and migration; metastasis; tumor microenvironment.