GATA4 as a maestro of gut regionalization

Licia Torres; Ana M C Faria

doi:10.1016/j.immuni.2022.12.015

GATA4 as a maestro of gut regionalization

Immunity. 2023 Jan 10;56(1):1-3. doi: 10.1016/j.immuni.2022.12.015.

Authors

Licia Torres¹, Ana M C Faria²

Affiliations

¹ Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
² Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: anacaetanofaria@gmail.com.

PMID: 36630909
DOI: 10.1016/j.immuni.2022.12.015

Abstract

How gut regionalization impacts microbiota and immunity is unclear. In this issue of Immunity, Earley et al. show that jejumal GATA4 expression controls bacteria colonization through retinol metabolism and IgA production. This metabolic-immune axis limits intestinal Th17 responses and immunopathology.

Publication types

Comment

MeSH terms

GATA4 Transcription Factor*
Gastrointestinal Microbiome*
Microbiota*
Th17 Cells / metabolism
Th17 Cells / microbiology

Substances

GATA4 protein, human
GATA4 Transcription Factor