Metabolism of 1-methyladenosine

Biochem Med Metab Biol. 1987 Aug;38(1):69-73. doi: 10.1016/0885-4505(87)90063-6.

Abstract

1-[methyl-8-14C] Adenosine was synthesized and its metabolic fate was determined in intact rat. It was found that approximately 57% of 1-[methyl-8-14C] adenosine administered iv was excreted unchanged in the urine and 33% of the excreted radioactivity in the urine was associated with the major metabolite 1-methyl-hypoxanthine and about 4.5% was associated with 1-methylinosine. Very little adenosine or N6-methyladenosine was formed. It is concluded that 1-methyladenosine is initially deaminated by adenosine deaminase to 1-methylinosine which is then cleaved by nucleoside phosphorylase to 1-methylhypoxanthine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenosine / administration & dosage
  • Adenosine / analogs & derivatives*
  • Adenosine / urine
  • Administration, Oral
  • Animals
  • Carbon Radioisotopes
  • Feces / analysis
  • Injections, Intravenous
  • Male
  • Rats
  • Rats, Inbred Strains
  • Tissue Distribution

Substances

  • Carbon Radioisotopes
  • 1-methyladenosine
  • Adenosine