Early pharmacokinetics and clinical effects of oral D-amphetamine in normal subjects

Biol Psychiatry. 1987 Nov;22(11):1357-68. doi: 10.1016/0006-3223(87)90070-9.


Seven normal subjects received 0.25 mg/kg D-amphetamine orally, both after an overnight fast and again after a standard breakfast. Plasma levels, subjective and cardiovascular effects, and observer-rated activation were assessed hourly for 5 hr. Food did not affect amphetamine levels. Plasma levels peaked at 2-3 hr. Maximum cardiovascular effects generally occurred at 1 hr, whereas maximum behavioral and subjective effects occurred at 2 hr. Subjective and behavioral effects declined thereafter, in spite of substantial amphetamine levels. A separate group of 8 subjects received 0.5 mg/kg D-amphetamine orally. Plasma levels, subjective and cardiovascular effects, and activation ratings were assessed hourly for 4 hr. Maximum plasma levels were approximately twice those seen in the first group. In this case, plasma levels peaked at 3-4 hr; blood pressure and subjective and behavioral effects were all maximal at 2-3 hr and were declining by 4 hr, in spite of stable or rising plasma levels.

MeSH terms

  • Administration, Oral
  • Adult
  • Arousal / drug effects*
  • Dextroamphetamine / pharmacokinetics*
  • Dextroamphetamine / pharmacology
  • Dose-Response Relationship, Drug
  • Female
  • Humans
  • Male
  • Middle Aged


  • Dextroamphetamine