The taxonomy of binding sites in proteins

Mol Cell Biochem. 1978 Nov 16;21(3):161-82. doi: 10.1007/BF00240135.

Abstract

Conservation of polypeptide fold and mode of ligand binding is frequently found within proteins of related function. Examples illustrating this phenomenon are taken from NAD linked enzymes, nucleotide binding proteins, polysaccharide binding proteins, heme binding proteins and enzymes with essential Fe--S complexes or zinc atoms.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Binding Sites*
  • Biological Evolution
  • Carrier Proteins* / classification
  • Carrier Proteins* / metabolism
  • Chemical Phenomena
  • Chemistry
  • Enzymes* / classification
  • Enzymes* / metabolism
  • Heme / metabolism
  • Iron-Sulfur Proteins
  • Metalloproteins
  • Models, Molecular
  • NADH, NADPH Oxidoreductases
  • Nucleotides / metabolism
  • Polysaccharides / metabolism
  • Protein Conformation
  • Zinc

Substances

  • Carrier Proteins
  • Enzymes
  • Iron-Sulfur Proteins
  • Metalloproteins
  • Nucleotides
  • Polysaccharides
  • Heme
  • NADH, NADPH Oxidoreductases
  • Zinc