Baricitinib Blocks Cytokine-Mediated Downregulation of PAD1 in Human Keratinocytes: A Possible Molecular Link to the Effects of JAK Inhibitors in Atopic Dermatitis

Avinash Padhi; Rokeya Sultana Rekha; Lisa Benrejdal; Marijke Elise Grundeken; Magda Lourda; Marcus Ehrström; Kilian Eyerich; Isabel Tapia Páez; Emma K Johansson; Maria Bradley; Peter Bergman; Josefin Lysell

doi:10.1016/j.jid.2022.12.012

Baricitinib Blocks Cytokine-Mediated Downregulation of PAD1 in Human Keratinocytes: A Possible Molecular Link to the Effects of JAK Inhibitors in Atopic Dermatitis

J Invest Dermatol. 2023 Jul;143(7):1306-1309.e4. doi: 10.1016/j.jid.2022.12.012. Epub 2023 Jan 11.

Authors

Affiliations

¹ Dermatology and Venereology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Division of Clinal Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
² Division of Clinal Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden.
³ Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden; Childhood Cancer Research Unit, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
⁴ Department of Reconstructive Plastic Surgery, Karolinska University Hospital Solna, Stockholm, Sweden.
⁵ Dermatology and Venereology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Dermatology and Venerology, Medical Center, University of Freiburg, Freiburg, Germany.
⁶ Dermatology and Venereology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
⁷ Dermatology and Venereology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden.
⁸ Division of Clinal Immunology, Department of Laboratory Medicine, Karolinska Institutet, Stockholm, Sweden; Department of Clinical Immunology and Transfusion Medicine, Karolinska University Hospital, Stockholm, Sweden.
⁹ Dermatology and Venereology Section, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Unit of Dermatology, Karolinska University Hospital, Stockholm, Sweden. Electronic address: josefin.lysell@ki.se.

PMID: 36641131
DOI: 10.1016/j.jid.2022.12.012

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Azetidines
Cytokines / metabolism
Dermatitis, Atopic* / drug therapy
Down-Regulation
Humans
Janus Kinase Inhibitors* / pharmacology
Janus Kinase Inhibitors* / therapeutic use
Keratinocytes / metabolism
Purines
Pyrazoles
Sulfonamides

Substances

Cytokines
Janus Kinase Inhibitors
baricitinib
Azetidines
Purines
Pyrazoles
Sulfonamides