Anticardiolipin antibodies in rheumatoid arthritis

Br J Rheumatol. 1987 Oct;26(5):346-50. doi: 10.1093/rheumatology/26.5.346.


Anticardiolipin antibody (ACA) was present in the sera of 49% of 90 consecutive patients with rheumatoid arthritis (RA). The ACA was absent in 30 control patients with osteoarthritis. C-reactive protein levels equal to or exceeding 7 mg/dl were found in 10 patients all of whom were ACA positive. ACA was present in a larger proportion of rheumatoid factor (RF) positive than of RF negative patients. Male sex and extra-articular manifestations of RA were both more common in ACA positive than ACA negative patients. In the ACA positive group the lupus anticoagulant and VDRL tests were negative. However, a small number of patients had evidence of vascular events.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / immunology*
  • Arthritis, Rheumatoid / pathology
  • Autoantibodies / analysis*
  • C-Reactive Protein / analysis
  • Cardiolipins / immunology*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Osteoarthritis / immunology
  • Rheumatoid Factor / analysis


  • Autoantibodies
  • Cardiolipins
  • C-Reactive Protein
  • Rheumatoid Factor