Diagnosis of Seronegative Rheumatoid Arthritis by 68 Ga-FAPI PET/CT

Shing Kee Cheung; Sirong Chen; Yuet Hung Wong; Kwan Kit Wu; Chi Lai Ho

doi:10.1007/s13139-022-00779-x

Diagnosis of Seronegative Rheumatoid Arthritis by ⁶⁸ Ga-FAPI PET/CT

Nucl Med Mol Imaging. 2023 Feb;57(1):44-45. doi: 10.1007/s13139-022-00779-x. Epub 2022 Oct 20.

Authors

Shing Kee Cheung¹, Sirong Chen^{1

2}, Yuet Hung Wong¹, Kwan Kit Wu¹, Chi Lai Ho¹

Affiliations

¹ Department of Nuclear Medicine & PET, Hong Kong Sanatorium & Hospital, 2 Village Road, Happy Valley, Hong Kong, China.
² Research Department, Hong Kong Sanatorium & Hospital, Hong Kong, China.

Abstract

Early diagnosis of rheumatoid arthritis with the initiation of disease-modifying antirheumatic drugs is important to prevent future disability. Seronegative rheumatoid arthritis lacks the classical immunological markers, thus imposing clinical diagnostic difficulty. In this case, we reported ⁶⁸ Ga-FAPI PET/CT findings of seronegative rheumatoid arthritis in a 60-year-old lady. This case illustrates how ⁶⁸ Ga-FAPI PET/CT aids in the diagnosis of seronegative rheumatoid arthritis.

Keywords: 68 Ga-FAPI; PET/CT; Seronegative rheumatoid arthritis; Synovial fibroblast.