Effect of natural beta-interferon on cell proliferation and steroid receptor level in human breast cancer cells

Cancer. 1987 Nov 15;60(10):2419-23. doi: 10.1002/1097-0142(19871115)60:10<2419::aid-cncr2820601011>3.0.co;2-s.

Abstract

The effect of natural beta-interferon (beta-IFN) on cell proliferation and steroid receptor level was investigated in CG-5 human breast cancer cell line. beta-interferon determines an appreciable diminution of cell growth, at concentrations ranging from 100 to 1000 IU/ml, which is enhanced when serum content of the culture medium is lowered. Low concentrations of beta-IFN (10-100 IU/ml) produce, after a 5-day treatment, an increase in estrogen receptors (ER) and progesterone receptors (PR). No variation of ER and PR levels is observed when beta-IFN is added directly to the cell homogenate before the assay. Our data suggest that beta-IFN could affect hormone sensitivity through a modification of ER and PR in neoplastic mammary cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / pathology*
  • Cell Division / drug effects
  • Cell Line
  • Female
  • Humans
  • Interferon Type I / pharmacology*
  • Neoplasms, Hormone-Dependent / pathology*
  • Receptors, Estrogen / analysis*
  • Receptors, Progesterone / analysis*
  • Tumor Cells, Cultured / analysis
  • Tumor Cells, Cultured / drug effects*

Substances

  • Interferon Type I
  • Receptors, Estrogen
  • Receptors, Progesterone