Pattern abnormalities induced by ectopic expression of the Drosophila gene hairy are associated with repression of ftz transcription

Cell. 1987 Nov 6;51(3):405-15. doi: 10.1016/0092-8674(87)90636-2.


The pair-rule segmentation gene hairy (h) is expressed and required in alternate metameres in the early Drosophila embryo. We show that h expression outside these domains, driven by an hsp70 promoter, suppresses the expression of fushi tarazu (ftz). The kinetics of action favor h acting directly as a transcriptional repressor. The resulting pattern defects, and the patterns of en and Ubx activity, can be explained if h acts via ftz and other pair-rule genes in the establishment of stable en domains. We present evidence that ftz is required for the initiation of Ubx transcription, but not for its maintenance.

MeSH terms

  • Animals
  • Chromosome Mapping
  • Drosophila / anatomy & histology
  • Drosophila / embryology
  • Drosophila / genetics*
  • Embryo, Nonmammalian / cytology
  • Genes*
  • Genetic Vectors
  • Mutation*
  • Phenotype
  • Plasmids
  • Transcription, Genetic*