Revisiting the manzamine biosynthetic hypothesis

Nat Prod Rep. 2023 Jan 17. doi: 10.1039/d2np00082b. Online ahead of print.


Covering: up to 2023The marine environment represents a rich yet challenging source of novel therapeutics. These challenges are best exemplified by the manzamine class of alkaloids, featuring potent bioactivities, difficult procurement, and a biosynthetic pathway that has eluded characterization for over three decades. This review highlights postulated biogenic pathways toward the manzamines, evaluated in terms of current biosynthetic knowledge and metabolic precedent.

Publication types

  • Review