Spatial heterogeneity of occlusive thrombus in acute ischemic stroke: A systematic review

J Neuroradiol. 2023 May;50(3):352-360. doi: 10.1016/j.neurad.2023.01.004. Epub 2023 Jan 14.


Following the advent of mechanical thrombectomy, occlusive clots in ischemic stroke have been amply characterized using conventional histopathology. Many studies have investigated the compositional variability of thrombi and the consequences of thrombus composition on treatment response. More recent evidence has emerged about the spatial heterogeneity of the clot or the preferential distribution of its components and compact nature. Here we review this emerging body of evidence, discuss its potential clinical implications, and propose the development of adequate characterization techniques.

Publication types

  • Systematic Review
  • Review

MeSH terms

  • Brain Ischemia* / complications
  • Brain Ischemia* / diagnostic imaging
  • Brain Ischemia* / pathology
  • Humans
  • Ischemic Stroke* / diagnostic imaging
  • Stroke* / therapy
  • Thrombectomy / methods
  • Thromboembolism*
  • Thrombosis* / complications
  • Thrombosis* / diagnostic imaging
  • Thrombosis* / pathology