Wildfire smoke exposure and emergency department visits for headache: A case-crossover analysis in California, 2006-2020

Abstract

Objective: To evaluate the association of short-term exposure to overall fine particulate matter of <2.5 μm (PM_2.5 ) and wildfire-specific PM_2.5 with emergency department (ED) visits for headache.

Background: Studies have reported associations between PM_2.5 exposure and headache risk. As climate change drives longer and more intense wildfire seasons, wildfire PM_2.5 may contribute to more frequent headaches.

Methods: Our study included adult Californian members (aged ≥18 years) of a large de-identified commercial and Medicare Advantage claims database from 2006 to 2020. We identified ED visits for primary headache disorders (subtypes: tension-type headache, migraine headache, cluster headache, and "other" primary headache). Claims included member age, sex, and residential zip code. We linked daily overall and wildfire-specific PM_2.5 to residential zip code and conducted a time-stratified case-crossover analysis considering 7-day average PM_2.5 concentrations, first for primary headache disorders combined, and then by headache subtype.

Results: Among 9898 unique individuals we identified 13,623 ED encounters for primary headache disorders. Migraine was the most frequently diagnosed headache (N = 5534/13,623 [47.6%]) followed by "other" primary headache (N = 6489/13,623 [40.6%]). For all primary headache ED diagnoses, we observed an association of 7-day average wildfire PM_2.5 (odds ratio [OR] 1.17, 95% confidence interval [CI] 0.95-1.44 per 10 μg/m³ increase) and by subtype we observed increased odds of ED visits associated with 7-day average wildfire PM_2.5 for tension-type headache (OR 1.42, 95% CI 0.91-2.22), "other" primary headache (OR 1.40, 95% CI 0.96-2.05), and cluster headache (OR 1.29, 95% CI 0.71-2.35), although these findings were not statistically significant under traditional null hypothesis testing. Overall PM_2.5 was associated with tension-type headache (OR 1.29, 95% CI 1.03-1.62), but not migraine, cluster, or "other" primary headaches.

Conclusions: Although imprecise, these results suggest short-term wildfire PM_2.5 exposure may be associated with ED visits for headache. Patients, healthcare providers, and systems may need to respond to increased headache-related healthcare needs in the wake of wildfires and on poor air quality days.

Keywords: case-crossover analysis; fine particulate matter of <2.5 μm (PM2.5); headache; wildfires.