Pulmonary veno-occlusive disease following therapy for malignant neoplasms

Chest. 1987 Nov;92(5):871-6. doi: 10.1378/chest.92.5.871.


We report three cases of pulmonary veno-occlusive disease which developed following treatment for malignant neoplasms. Two patients received single agent BCNU chemotherapy for malignant gliomas. The third patient underwent combination radiation and chemotherapy for Hodgkin's disease. Isolated case reports of pulmonary veno-occlusive disease following therapy for malignant disease are reviewed and clinical features summarized. Pulmonary veno-occlusive disease in this setting is thought to be rare. However, the diagnosis is rarely suspected clinically and is difficult to diagnose pathologically. Therefore, the true incidence of this complication is unknown and may be higher than believed. It is important that both clinician and pathologist be aware of this entity; otherwise, elastic tissue stains may not be performed and the diagnosis missed.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Biopsy
  • Brain Neoplasms / drug therapy
  • Carmustine / adverse effects
  • Carmustine / therapeutic use
  • Combined Modality Therapy
  • Female
  • Hodgkin Disease / drug therapy
  • Hodgkin Disease / radiotherapy
  • Humans
  • Lung / diagnostic imaging
  • Lung / pathology
  • Male
  • Neoplasms / drug therapy*
  • Neoplasms / radiotherapy
  • Pulmonary Veno-Occlusive Disease / chemically induced
  • Pulmonary Veno-Occlusive Disease / diagnostic imaging
  • Pulmonary Veno-Occlusive Disease / etiology*
  • Pulmonary Veno-Occlusive Disease / pathology
  • Radiography


  • Carmustine