Molecular Pathogenesis of Nipah Virus

Appl Biochem Biotechnol. 2023 Apr;195(4):2451-2462. doi: 10.1007/s12010-022-04300-0. Epub 2023 Jan 19.

Abstract

Viral diseases are causing mayhem throughout the world. One of the zoonotic viruses that have emerged as a potent threat to community health in the past few decades is Nipah virus. Nipah viral sickness is a zoonotic disease whose main carrier is bat. This disease is caused by Nipah virus (NiV). It belongs to the henipavirous group and of the family paramyxoviridae. Predominantly Pteropus spp. is the carrier of this virus. It was first reported from the Kampung Sungai Nipah town of Malaysia in 1998. Human-to-human transmission can also occur. Several repeated outbreaks were reported from South and Southeast Asia in the recent past. In humans, the disease is responsible for rapid development of acute illness, which can result in severe respiratory illness and serious encephalitis. Therefore, this calls for an urgent need for health authorities to conduct clinical trials to establish possible treatment regimens to prevent any further outbreaks.

Keywords: Encephalitis; Epidemiology; Nipah virus (NiV); Pathology; Septicemia; Seroprevalence; Zoonotic.

Publication types

  • Review

MeSH terms

  • Animals
  • Chiroptera*
  • Disease Outbreaks
  • Henipavirus Infections* / epidemiology
  • Henipavirus Infections* / prevention & control
  • Humans
  • Nipah Virus* / genetics
  • Zoonoses / epidemiology
  • Zoonoses / prevention & control