miR-124-3p mediates polygenic risk shared between schizophrenia and bipolar disorder

Neuron. 2023 Jan 18;111(2):144-146. doi: 10.1016/j.neuron.2022.12.024.


In this issue of Neuron, Namkung et al. demonstrate that the microRNA miR-124-3p is associated with polygenic risk scores shared between schizophrenia and bipolar disorder and confers risk to behavioral alterations common to these two disorders through modulation of AMPA receptor neurotransmission.

Publication types

  • Comment

MeSH terms

  • Bipolar Disorder* / genetics
  • Genetic Predisposition to Disease / genetics
  • Humans
  • MicroRNAs* / genetics
  • Multifactorial Inheritance / genetics
  • Risk Factors
  • Schizophrenia* / genetics


  • MicroRNAs
  • MIRN124 microRNA, human