Optochin resistance in Streptococcus pneumoniae strains isolated from blood and middle ear fluid

Eur J Clin Microbiol. 1987 Aug;6(4):422-4. doi: 10.1007/BF02013101.


Optochin resistant Streptococcus pneumoniae having typical pneumococcal morphology in culture and Gram stain and giving clear agglutination with anti-pneumococcal polysaccharide antisera were isolated from primary cultures of blood and middle ear fluid. The isolated pneumococci were either fully sensitive to penicillin and other antimicrobial agents commonly used or relatively resistant to penicillin and resistant to cloxacillin, tetracycline, erythromycin, sulphatrimethoprim and clindamycin.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Agglutination Tests
  • Drug Resistance, Microbial
  • Ear, Middle / microbiology*
  • Humans
  • Infant
  • Male
  • Otitis Media / microbiology*
  • Otitis Media, Suppurative / microbiology*
  • Pneumococcal Infections / microbiology
  • Quinine / analogs & derivatives*
  • Quinine / pharmacology
  • Sepsis / microbiology*
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / isolation & purification


  • ethylhydrocupreine
  • Quinine