Effect of azapropazone and allopurinol on myocardial infarct size in rats

Eur J Pharmacol. 1987 Aug 11;140(2):203-7. doi: 10.1016/0014-2999(87)90806-5.


The effect of the xanthine oxidase inhibitor allopurinol and the non-steroidal antiinflammatory agent azapropazone on infarct size in rats, subjected to 48 h of occlusion of the left anterior descending coronary artery, were studied. Allopurinol (50 mg/kg i.p., twice daily from 24 h before to 48 h after LAD occlusion) and azapropazone (100 mg/kg i.p twice daily from 24 h before to 48 h after LAD occlusion) significantly reduced infarct size when compared to saline-treated rats. These data point towards involvement of xanthine oxidase derived free radicals in evolving myocardial infarction in rats; beneficial effect of azapropazone in this model may be related to the drug's ability to inhibit xanthine oxidase as well as various key neutrophil functions.

MeSH terms

  • Allopurinol / pharmacology*
  • Animals
  • Apazone / pharmacology*
  • Male
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / pathology
  • Rats
  • Rats, Inbred Strains
  • Triazines / pharmacology*


  • Triazines
  • Allopurinol
  • Apazone