Primary structures of human protein kinase C beta I and beta II differ only in their C-terminal sequences

FEBS Lett. 1987 Oct 19;223(1):138-42. doi: 10.1016/0014-5793(87)80524-0.

Abstract

Two types of cDNA clones encoding human protein kinase C (PKC) were isolated from a spleen cDNA library using rabbit protein kinase C beta I/beta II cDNA as a hybridization probe. Nucleotide sequence analyses of these cDNA inserts revealed complete primary structures of two distinct types of human protein kinase C beta I and beta II which differ only in their C-terminal 50 or 52 amino acid residues. It was concluded that there exist four distinct types of PKC, PKC alpha, beta I, beta II and gamma, in human as well as rabbit, and that the corresponding sequences are strictly conserved among mammalian species.

Publication types

  • Comparative Study

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • DNA / genetics
  • Humans
  • Molecular Sequence Data
  • Protein Kinase C / genetics*
  • RNA, Messenger / genetics
  • Sequence Homology, Nucleic Acid
  • Spleen / physiology

Substances

  • RNA, Messenger
  • DNA
  • Protein Kinase C

Associated data

  • GENBANK/X06318
  • GENBANK/X07109