Differences in Preoperative Health-Related Quality of Life between Women Receiving Mastectomy or Breast Conserving Surgery in a Prospectively Recruited Cohort of Breast Cancer Patients

Curr Oncol. 2022 Dec 22;30(1):118-129. doi: 10.3390/curroncol30010010.


As rates of total mastectomy rise, the relationships between surgery modality with domains of health-related quality of life is not well understood. This study reports differences in depression, anxiety, pain, and health status among a cohort of women scheduled to receive total mastectomy or breast-conserving surgery. Patient-reported outcomes measured preoperative differences between patients receiving total mastectomy or breast-conserving surgery in a cross-sectional design. Regression analyses was used to model health outcomes and adjust for patient demographics on patient measures. Participants scheduled for total mastectomy were more likely to report more severe symptoms of depression and anxiety. This association was non-significant after adjusting for demographic differences. Younger participants were more likely to be scheduled for total mastectomy. Age was negatively associated with symptoms of depression and anxiety. Screening patients for mental health symptoms may be particularly important among younger patients who were more likely to report depression and anxiety before their surgery and were more likely to receive total mastectomy.

Keywords: breast cancer; breast conserving surgery; health-related quality of life; partial mastectomy; total mastectomy.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms* / complications
  • Cross-Sectional Studies
  • Female
  • Humans
  • Mastectomy* / psychology
  • Mastectomy, Segmental / psychology
  • Quality of Life / psychology

Grants and funding

This research supported by in-kind assistance from Providence Health Canada (Vancouver, BC, Canada) and Vancouver Coastal Health Authority. There were no other funders. These institutions had no input on the design of the study, statistical analyses, or interpretation of the results. The authors report no conflicts of interest.