Associations of WWC1 variants with Alzheimer's disease and vascular dementia among rural older adults in China: A population-based study

Neurobiol Aging. 2023 May:125:109-114. doi: 10.1016/j.neurobiolaging.2023.01.003. Epub 2023 Jan 8.

Abstract

We sought to examine the associations of common WWC1 variants with Alzheimer's disease (AD) and vascular dementia (VaD) among rural-dwelling older adults in China. This population-based study used data from the baseline assessments (March -September 2018) of MIND-China. AD and VaD were diagnosed following the international criteria. Of the 5455 participants (age≥60 years, 57.27% women), 182 were diagnosed with AD and 88 with VaD. Logistic regression analysis suggested that WWC1 rs17070145 C allele (vs. T) was associated with multivariable-adjusted odds ratio of 1.23 (95% confidence interval 0.96-1.58) for AD, and that CC genotype (vs. TT) was associated with multivariable-adjusted odds ratio of 2.19(1.10-4.39) for VaD, but the association with VaD became non-significant when further adjusting for stroke history. Furthermore, exonic SNPs rs3822660 and rs3822659 were in strong linkage disequilibrium (LD) with rs17070145 (D' = 0.88). These results suggest that the strong LD between rs17070145 and 2 exonic SNPs may explain the association of WWC1 rs17070145 C allele with AD and that stroke may partly explain the association of WWC1 rs17070145 CC genotype with VaD.

Keywords: Alzheimer's disease; Population-based study; Vascular dementia; WWC1 rs17070145.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Alzheimer Disease* / diagnosis
  • Alzheimer Disease* / epidemiology
  • Alzheimer Disease* / genetics
  • China / epidemiology
  • Dementia, Vascular* / diagnosis
  • Dementia, Vascular* / genetics
  • Female
  • Genotype
  • Humans
  • Intracellular Signaling Peptides and Proteins / genetics
  • Male
  • Polymorphism, Single Nucleotide / genetics
  • Stroke*

Substances

  • WWC1 protein, human
  • Intracellular Signaling Peptides and Proteins

Associated data

  • ChiCTR/ChiCTR1800017758