A new sustained-release theophylline suspension for asthmatic children: evaluation of serum theophylline concentrations

Int J Clin Pharmacol Res. 1987;7(5):345-50.


Theophylline level variability obtained with standard slow-release theophylline tablets was compared to that obtained with a new sustained-release theophylline suspension in asthmatic children. The sustained-release preparations were administered every 12 hours and serum samples were collected after ten days of treatment during the steady-state period. In this crossover study, the sequence of the two regimens (slow-release tablets versus slow-release suspension) was selected at random. Both preparations of theophylline were administered at a mean dosage (+/- s.d.) of 19.3 +/- 1 mg/kg/day. The results of our study demonstrated that theophylline serum levels remain within the therapeutic range for both preparations, but there was a greater fluctuation with theophylline suspension compared to the tablets. The tolerability of the two drugs was satisfactory.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adolescent
  • Asthma / blood
  • Asthma / drug therapy*
  • Child
  • Delayed-Action Preparations
  • Humans
  • Theophylline / administration & dosage*
  • Theophylline / blood


  • Delayed-Action Preparations
  • Theophylline