Design and Preparation of Sensing Surfaces for Capacitive Biodetection

Biosensors (Basel). 2022 Dec 23;13(1):17. doi: 10.3390/bios13010017.

Abstract

Despite their high sensitivity and their suitability for miniaturization, biosensors are still limited for clinical applications due to the lack of reproducibility and specificity of their detection performance. The design and preparation of sensing surfaces are suspected to be a cause of these limitations. Here, we first present an updated overview of the current state of use of capacitive biosensors in a medical context. Then, we summarize the encountered strategies for the fabrication of capacitive biosensing surfaces. Finally, we describe the characteristics which govern the performance of the sensing surfaces, along with recent developments that were suggested to overcome their main current limitations.

Keywords: biomolecules immobilization; biosensors; capacitive detection; electrochemical impedance spectroscopy; interdigitated electrodes; non-faradaic impedance; surface functionalization.

Publication types

  • Review

MeSH terms

  • Biosensing Techniques*
  • Electrochemical Techniques
  • Electrodes
  • Reproducibility of Results