Lack of Association between Common LAG3/CD4 Variants and Risk of Migraine

Int J Mol Sci. 2023 Jan 9;24(2):1292. doi: 10.3390/ijms24021292.


Several papers have been published suggesting a probable role of inflammatory factors in the etiopathogenesis of migraine. In this study, we investigated the possible association between common variants in the LAG3/CD4 genes (both genes, which are closely related, encode proteins involved in inflammatory and autoimmune responses) in the risk of migraine in a cohort of Caucasian Spanish participants. For this purpose, the frequencies of CD4 rs1922452, CD4 rs951818, and LAG3 rs870849 genotypes and allelic variants, using a specific TaqMan-based qPCR assay, were assessed in 290 patients diagnosed with migraine and in 300 healthy controls. The relationship of these variables with several clinical features of migraine was also analyzed. The frequencies of the analyzed LAG3/CD4 genotypes did not differ significantly between the two study groups and were not related to the sex, age at onset of migraine, family history of migraine, presence or absence of aura, or the triggering effect of ethanol on migraine episodes. These results suggest a lack of association between common variants in the LAG3/CD4 genes and the risk of developing migraine in the Caucasian Spanish population.

Keywords: CD4 gene; LAG3 gene; genetic polymorphisms; genetics; inflammatory factors; migraine; risk factors.

MeSH terms

  • CD4 Antigens* / genetics
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Lymphocyte Activation Gene 3 Protein* / genetics
  • Migraine Disorders* / genetics
  • Polymorphism, Single Nucleotide
  • Risk Factors


  • CD4 Antigens
  • Lag3 protein, human
  • Lymphocyte Activation Gene 3 Protein