Abstract
A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.
Keywords:
2-phenethylamine; 5-HT; DAT; MAO; PPAR; TAAR1; adrenoceptors; carbonyl anhydrase; dopamine receptor; ligands; medicinal chemistry; sigma receptors.
MeSH terms
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Chemistry, Pharmaceutical*
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Phenethylamines / chemistry
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Phenethylamines / pharmacology
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Receptors, Dopamine D2
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Receptors, G-Protein-Coupled*
Substances
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phenethylamine
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Receptors, G-Protein-Coupled
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Phenethylamines
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Receptors, Dopamine D2
Grant support
The authors gratefully acknowledge the financial support of this work provided by Ministerio de Ciencia e Innovación (PID2020-118303GB-I00/MCIN/AEI/10.13039/501100011033) and Junta de Castilla y Leon (SA0076P20). C.T.N. thanks Junta de Castilla y Leon for a postdoctoral contract (SA0076P20).