2-Phenethylamines in Medicinal Chemistry: A Review

Molecules. 2023 Jan 14;28(2):855. doi: 10.3390/molecules28020855.


A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.

Keywords: 2-phenethylamine; 5-HT; DAT; MAO; PPAR; TAAR1; adrenoceptors; carbonyl anhydrase; dopamine receptor; ligands; medicinal chemistry; sigma receptors.

Publication types

  • Review

MeSH terms

  • Chemistry, Pharmaceutical*
  • Phenethylamines / chemistry
  • Phenethylamines / pharmacology
  • Receptors, Dopamine D2
  • Receptors, G-Protein-Coupled*


  • phenethylamine
  • Receptors, G-Protein-Coupled
  • Phenethylamines
  • Receptors, Dopamine D2

Grant support

The authors gratefully acknowledge the financial support of this work provided by Ministerio de Ciencia e Innovación (PID2020-118303GB-I00/MCIN/AEI/10.13039/501100011033) and Junta de Castilla y Leon (SA0076P20). C.T.N. thanks Junta de Castilla y Leon for a postdoctoral contract (SA0076P20).