2-Phenethylamines in Medicinal Chemistry: A Review

Carlos T Nieto; Alejandro Manchado; Leland Belda; David Diez; Narciso M Garrido

doi:10.3390/molecules28020855

2-Phenethylamines in Medicinal Chemistry: A Review

Molecules. 2023 Jan 14;28(2):855. doi: 10.3390/molecules28020855.

Authors

Carlos T Nieto¹, Alejandro Manchado¹, Leland Belda¹, David Diez¹, Narciso M Garrido¹

Affiliation

¹ Department of Organic Chemistry, Faculty of Chemical Sciences, University of Salamanca, Pl. Caídos, s/n, 37008 Salamanca, Spain.

Abstract

A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and appealing screening compounds. Latest reports in discovering new bioactive 2-phenethylamines by research groups are covered too.

Keywords: 2-phenethylamine; 5-HT; DAT; MAO; PPAR; TAAR1; adrenoceptors; carbonyl anhydrase; dopamine receptor; ligands; medicinal chemistry; sigma receptors.

Publication types

Review

MeSH terms

Chemistry, Pharmaceutical*
Phenethylamines / chemistry
Phenethylamines / pharmacology
Receptors, Dopamine D2
Receptors, G-Protein-Coupled*

Substances

phenethylamine
Receptors, G-Protein-Coupled
Phenethylamines
Receptors, Dopamine D2

Grant support

The authors gratefully acknowledge the financial support of this work provided by Ministerio de Ciencia e Innovación (PID2020-118303GB-I00/MCIN/AEI/10.13039/501100011033) and Junta de Castilla y Leon (SA0076P20). C.T.N. thanks Junta de Castilla y Leon for a postdoctoral contract (SA0076P20).