Drug Repositioning for Hand, Foot, and Mouth Disease

Ran Yan; Jiahao He; Ge Liu; Jianfeng Zhong; Jiapeng Xu; Kai Zheng; Zhe Ren; Zhendan He; Qinchang Zhu

doi:10.3390/v15010075

Drug Repositioning for Hand, Foot, and Mouth Disease

Viruses. 2022 Dec 27;15(1):75. doi: 10.3390/v15010075.

Authors

Ran Yan^{1

2}, Jiahao He¹, Ge Liu², Jianfeng Zhong¹, Jiapeng Xu², Kai Zheng¹, Zhe Ren^{3

4}, Zhendan He¹, Qinchang Zhu²

Affiliations

¹ School of Pharmaceutical Sciences, Shenzhen University, Shenzhen 518060, China.
² College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, China.
³ Institute of Biomedicine, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
⁴ National Engineering Research Center of Genetic Medicine, Guangzhou 510632, China.

Abstract

Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice. Drug repositioning is an attractive drug discovery strategy aimed at identifying and developing new drugs for diseases. Notably, repositioning of well-characterized therapeutics, including either approved or investigational drugs, is becoming a potential strategy to identify new treatments for virus infections. Various types of drugs, including antibacterial, cardiovascular, and anticancer agents, have been studied in relation to their therapeutic potential to treat HFMD. In this review, we summarize the major outbreaks of HFMD and the progress in drug repositioning to treat this disease. We also discuss the structural features and mode of action of these repositioned drugs and highlight the opportunities and challenges of drug repositioning for HFMD.

Keywords: HFMD; drug repositioning; drug repurposing; enteroviruses.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Child
Child, Preschool
China / epidemiology
Disease Outbreaks
Drug Repositioning
Enterovirus Infections*
Enterovirus*
Hand, Foot and Mouth Disease* / drug therapy
Hand, Foot and Mouth Disease* / epidemiology
Humans
Infant

Grants and funding

This project was funded by the Science and Technology Program of Guangdong Province (2018A030313252), the Shenzhen Fundamental Research Program (JCYJ20190808122605563 and JCYJ20220530153206014), the Natural Science Foundation of Top Talent of SZTU (GDRC202121), and the Fundamental Research Funds for Shenzhen Technology University.