Left atrial appendage closure in end-stage renal disease and hemodialysis: Data from a German multicenter registry

Catheter Cardiovasc Interv. 2023 Feb;101(3):610-619. doi: 10.1002/ccd.30559. Epub 2023 Jan 22.


Background: Left atrial appendage closure (LAAC) has emerged as an alternative to oral anticoagulation (OAC) for stroke prevention in patients with atrial fibrillation (AF). OAC treatment has been proven feasible in mild-to-moderate chronic kidney disease (CKD). In contrast, the optimal antithrombotic management of AF patients with end-stage renal disease (ESRD) is unknown and LAAC has not been proven in these patients in prospective randomized clinical trials.

Objectives: The objective of this study is to evaluate safety and efficacy of LAAC in patients with ESRD.

Methods: Patients undergoing LAAC were collected in a German multicenter real-world observational registry. A composite endpoint consisting of the occurrence of ischemic stroke/transient ischemic attack, systemic embolism, and/or major clinical bleeding was assessed. Patients with ESRD were compared with propensity score-matched patients without severe CKD. ESRD was defined as a glomerular filtration rate < 15 ml/min/1.73 m2 or chronic hemodialysis treatment.

Results: A total of 604 patients were analyzed, including 57 with ESRD and 57 propensity-matched patients. Overall, 596 endocardial and 8 epicardial LAAC procedures were performed. Frequency of major complications was 7.0% (42/604 patients) in the overall cohort, 8.8% (5/57 patients) in patients with ESRD, and 10.5% (6/57 patients) in matched controls (p = 0.75). The estimated event-free survival of the combined endpoint after 500 days was 90.7 ± 4.5% in patients with ESRD and 90.2 ± 5.5% in matched controls (p = 0.33).

Conclusions: LAAC had comparable procedural safety and clinical efficacy in patients with ESRD and patients without severe CKD.

Keywords: chronic kidney disease; hemodialysis; left atrial appendage closure; renal failure; stroke.

Publication types

  • Multicenter Study

MeSH terms

  • Anticoagulants / adverse effects
  • Atrial Appendage* / diagnostic imaging
  • Atrial Fibrillation* / complications
  • Atrial Fibrillation* / diagnosis
  • Atrial Fibrillation* / therapy
  • Humans
  • Kidney Failure, Chronic* / complications
  • Kidney Failure, Chronic* / diagnosis
  • Kidney Failure, Chronic* / therapy
  • Prospective Studies
  • Registries
  • Renal Dialysis / adverse effects
  • Renal Insufficiency, Chronic* / complications
  • Renal Insufficiency, Chronic* / diagnosis
  • Renal Insufficiency, Chronic* / therapy
  • Stroke* / etiology
  • Stroke* / prevention & control
  • Treatment Outcome


  • Anticoagulants