Antifilarial effect of Zingiber officinale on Dirofilaria immitis

J Helminthol. 1987 Sep;61(3):268-70. doi: 10.1017/s0022149x00010142.


Dogs, naturally infected with Dirofilaria immitis, were treated with the residues of the alcoholic extracts of the rhizomes of Zingiber officinale (ginger). Twelve subcutaneous injections of the extract given at 100 mg/kg reduced microfilarial concentration in blood by a maximum of 98%. Fifty five days after the last injection there was 83% reduction in microfilarial concentration suggesting partial destruction of adult worms. Half of the treated dogs showed some lethargy at the beginning of treatment possibly due to the mass annihilation of microfilariae in blood.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anthelmintics / therapeutic use*
  • Dirofilaria immitis / drug effects
  • Dirofilariasis / drug therapy
  • Dirofilariasis / veterinary*
  • Dog Diseases / drug therapy*
  • Dogs
  • Female
  • Filaricides / therapeutic use*
  • Male
  • Microfilariae / drug effects
  • Plant Extracts / therapeutic use*


  • Anthelmintics
  • Filaricides
  • Plant Extracts