A complex equation - adding to Plasmodium falciparum invasion

Kasper H Björnsson; Lea Barfod

doi:10.1016/j.pt.2023.01.004

A complex equation - adding to Plasmodium falciparum invasion

Trends Parasitol. 2023 Mar;39(3):160-162. doi: 10.1016/j.pt.2023.01.004. Epub 2023 Jan 21.

Authors

Kasper H Björnsson¹, Lea Barfod²

Affiliations

¹ Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
² Centre for Medical Parasitology, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Electronic address: lbarfod@sund.ku.dk.

PMID: 36682939
DOI: 10.1016/j.pt.2023.01.004

Abstract

The Plasmodium falciparum invasion complex - consisting of the prime blood-stage vaccine candidates PfRH5, PfCyRPA and PfRipr - is essential and conserved. New data from Scally et al. reveal that the complex consists of two additional proteins, adding important knowledge to the current understanding of the biology behind the invasion process.

Keywords: PfCyRPA; PfRH5; PfRipr; Plasmodium falciparum; blood-stage vaccines; erythrocyte invasion.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Protozoan
Antigens, Protozoan / metabolism
Carrier Proteins / metabolism
Erythrocytes
Humans
Malaria Vaccines*
Malaria, Falciparum* / prevention & control
Plasmodium falciparum
Protozoan Proteins / metabolism

Substances

Protozoan Proteins
Antigens, Protozoan
Carrier Proteins
Antibodies, Protozoan
Malaria Vaccines