A complex equation - adding to Plasmodium falciparum invasion

Trends Parasitol. 2023 Mar;39(3):160-162. doi: 10.1016/j.pt.2023.01.004. Epub 2023 Jan 21.


The Plasmodium falciparum invasion complex - consisting of the prime blood-stage vaccine candidates PfRH5, PfCyRPA and PfRipr - is essential and conserved. New data from Scally et al. reveal that the complex consists of two additional proteins, adding important knowledge to the current understanding of the biology behind the invasion process.

Keywords: PfCyRPA; PfRH5; PfRipr; Plasmodium falciparum; blood-stage vaccines; erythrocyte invasion.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Protozoan
  • Antigens, Protozoan / metabolism
  • Carrier Proteins / metabolism
  • Erythrocytes
  • Humans
  • Malaria Vaccines*
  • Malaria, Falciparum* / prevention & control
  • Plasmodium falciparum
  • Protozoan Proteins / metabolism


  • Protozoan Proteins
  • Antigens, Protozoan
  • Carrier Proteins
  • Antibodies, Protozoan
  • Malaria Vaccines