Case report: Primary intracranial mucosa-associated lymphoid tissue lymphoma presenting as two primary tumors involving the cavernous sinus and extra-axial dura, respectively

Shiyun Tian; Tao Pan; Bingbing Gao; Wanyao Li; Jiashen Liu; Kun Zou; Yanwei Miao

doi:10.3389/fonc.2022.927086

Case report: Primary intracranial mucosa-associated lymphoid tissue lymphoma presenting as two primary tumors involving the cavernous sinus and extra-axial dura, respectively

Front Oncol. 2023 Jan 4:12:927086. doi: 10.3389/fonc.2022.927086. eCollection 2022.

Authors

Shiyun Tian¹, Tao Pan², Bingbing Gao¹, Wanyao Li¹, Jiashen Liu³, Kun Zou⁴, Yanwei Miao¹

Affiliations

¹ Department of Radiology, First Affiliated Hospital of Dalian Medical University, Dalian, China.
² The Interventional Therapy Department, First Affiliated Hospital, Dalian Medical University, Dalian, China.
³ Department of Pathology, First Affiliated Hospital, Dalian Medical University, Dalian, China.
⁴ Department of Radiation Therapy, First Affiliated Hospital, Dalian Medical University, Dalian, China.

Abstract

Primary intracranial mucosa-associated lymphoid tissue (MALT) lymphoma is a rare type of brain tumor, with only a few reported cases worldwide that mostly have only one lesion with conventional magnetic resonance imaging (MRI) findings. Here, we present a special case of intracranial MALT lymphoma with two mass lesions radiographically consistent with meningiomas on MRI before the operation. A 66-year-old woman was admitted to the hospital with intermittent right facial pain for 1 year, aggravated for the last month. Brain MRI showed two extracerebral solid masses with similar MR signal intensity. One mass was crescent-shaped beneath the skull, and the other was in the cavernous sinus area. Lesions showed isointensity on T1WI and T2WI and an intense homogeneous enhancement after contrast agent injection. Both lesions showed hyperintensity in amide proton transfer-weighted images. The two masses were all surgically resected. The postoperative pathology indicated extranodal marginal zone B-cell lymphoma of MALT. To improve awareness of intracranial MALT lymphoma in the differential diagnosis of extra-axial lesions among clinicians, we present this report and briefly summarize previously reported cases to describe the clinical, pathological, radiological, and treatment features.

Keywords: central nervous system; extranodal marginal zone lymphoma; magnetic resonance imaging; mucosa-associated lymphoid tissue; primary intracranial tumor; treatment.

Publication types

Case Reports