Discussion on gemcitabine combined with targeted drugs in the treatment of pancreatic cancer

World J Gastroenterol. 2023 Jan 21;29(3):579-581. doi: 10.3748/wjg.v29.i3.579.


Pancreatic cancer is a malignant tumor with poor prognosis. The treatment of pancreatic cancer depends on the tumor stage and type, and includes local treatment (surgery, radiotherapy and ablation intervention) and systemic therapy (chemotherapy, targeted therapy and immunotherapy). We read with great interest the review "Effective combinations of anti-cancer and targeted drugs for pancreatic cancer treatment" published on World J Gastroenterol and intended to share some of our perspectives in pancreatic cancer treatment. This review presents the therapeutic effects of the combination of gemcitabine and targeted drugs, which gives us a deeper insight into the combination treatments for pancreatic cancer.

Keywords: Chemotherapy; Combination; Drug; Gemcitabine; Pancreatic cancer; Targeted therapy.

Publication types

  • Review

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / adverse effects
  • Combined Modality Therapy
  • Deoxycytidine / therapeutic use
  • Gemcitabine*
  • Humans
  • Pancreatic Neoplasms* / pathology


  • Gemcitabine
  • Deoxycytidine

Supplementary concepts

  • Pancreatic Carcinoma