Sublimation of Benign Conjunctival Nevi Using Plasma-Assisted Noninvasive Surgery: A Clinical Case Series

Iran J Med Sci. 2023 Jan;48(1):85-90. doi: 10.30476/IJMS.2022.93665.2494.


Background: Conjunctival nevi (CN) are common benign ocular tumors. Given their low risk of malignancy, surgical removal of nevi is primarily requested by patients. Herein, we introduce Atmospheric Low-temperature Plasma (ALTP) as a novel noninvasive method for the removal of CN.

Methods: A clinical case series was conducted from 2020 to 2021 at the Vision Health Ophthalmic Center in Tehran, Iran. CN in one of the eyes of seven patients was treated. In all patients, the benignity of CN was confirmed by ocular oncologists. The white handpiece of the Plexr device, which generates plasma with the lowest output, was used to apply plasma spots on the nevi. In addition, the Ocular Surface Disease Index (OSDI) questionnaire was completed by all patients before and six months after the treatment.

Results: In all patients, the nevi outside the limbus area completely disappeared. The mean size of pre- and post-operative nevi was 3.89×11.7 and 0.54×1.69 mm, respectively. Results of the OSDI questionnaire showed significantly lower scores after the surgery in all patients.

Conclusion: The ALTP method is a simple, cost-effective, and office-based surgery to remove CN safely and effectively.

Keywords: Conjunctiva; Nevus; Plasma; Plasma-assisted noninvasive surgery; Sublimation.

MeSH terms

  • Conjunctival Neoplasms* / pathology
  • Conjunctival Neoplasms* / surgery
  • Humans
  • Iran
  • Nevus* / pathology
  • Nevus, Pigmented* / pathology
  • Nevus, Pigmented* / surgery
  • Skin Neoplasms*