Vascular Malformations: A Histopathologic and Conceptual Appraisal

Actas Dermosifiliogr. 2023 Mar;114(3):T213-T228. doi: 10.1016/ Epub 2023 Jan 20.
[Article in English, Spanish]


In the field of vascular anomalies, distinguishing between vascular malformations and tumors has become crucial for a correct therapeutic approach. However, the differential diagnosis between these two groups is not always well explained in classical texts, mainly because many vascular malformations are still known with old names that suggest a tumoral nature. Also, genetic and pathogenic knowledge of these entities has greatly increased in recent decades, so researchers and clinicians now have a better understanding of vascular malformations. In this paper, we present the main histopathological tips to recognize and identify a vascular malformation as such. We also contextualize such information in the clinical and pathogenic knowledge for a better understanding of these entities.

Keywords: Anomalías vasculares; Cavernous hemangioma; Hemangioma cavernoso; ISSVA; Linfangioma; Lymphangioma; Malformación vascular; Vascular anomalies; Vascular malformation.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Hemangioma* / pathology
  • Humans
  • Vascular Malformations* / diagnosis
  • Vascular Malformations* / therapy