Effect of glycerol and dibutyl phthalate on modified natural rubber latex based drug delivery systems

Janisha Jayadevan; Monisha Manathanath; Mekha Mariam Mathew; Unnikrishnan Gopalakrishna Panicker

doi:10.1016/j.ijbiomac.2023.123286

Effect of glycerol and dibutyl phthalate on modified natural rubber latex based drug delivery systems

Int J Biol Macromol. 2023 Mar 15:231:123286. doi: 10.1016/j.ijbiomac.2023.123286. Epub 2023 Jan 20.

Authors

Janisha Jayadevan¹, Monisha Manathanath¹, Mekha Mariam Mathew¹, Unnikrishnan Gopalakrishna Panicker²

Affiliations

¹ Department of Chemistry, NIT Calicut, Kerala 673601, India.
² Department of Chemistry, NIT Calicut, Kerala 673601, India. Electronic address: unnig@nitc.ac.in.

PMID: 36690239
DOI: 10.1016/j.ijbiomac.2023.123286

Abstract

The work highlights the impact of the incorporation of two pharmaceutical plasticizers viz.; glycerol (GLY; hydrophilic) and dibutyl phthalate (DBP; hydrophobic) on the controlled drug release features of a deproteinised natural rubber latex (DNRL) -based matrix. The effects of the plasticizers on the mechanical properties, glass transition temperature (T_g), water absorption behaviour and porosity of DNRL have been initially investigated. The plasticized membranes have been found to show a hemolysis percentage (HP) of <5 %; confirming its compatibility with human blood. The potential of the modified DNRL membranes to function as drug carriers have been examined with metformin hydrochloride (MET) as a model drug.

Keywords: Blend membranes; Drug release; Hemolysis; Natural rubber latex; Plasticizers; Skin compatibility.

MeSH terms

Dibutyl Phthalate* / chemistry
Drug Delivery Systems
Glycerol
Humans
Latex / chemistry
Plasticizers / chemistry
Rubber* / chemistry

Substances

Rubber
Dibutyl Phthalate
Latex
Glycerol
Plasticizers