Use of Capillary Electrophoresis Migration Position for the Presumptive Identification of Hemoglobin Variants Prevalent in China

Hemoglobin. 2022 Nov;46(6):330-334. doi: 10.1080/03630269.2022.2151463. Epub 2023 Jan 25.

Abstract

Capillary electrophoresis (CE) is increasingly being used to screen for hemoglobinopathies. We here report the migration position of hemoglobin (Hb) variants prevalent in China determined by CE. The CE migration position showed excellent precision and minor inter-individual variation. We conclude that the CE migration position can be used as a reliable indicator for identifying Hb variants and can also help to establish a well-characterized library of Hb variants for their refined presumptive identification.

Keywords: Capillary electrophoresis (CE); hemoglobin (Hb) variants; migration position; presumptive identification.

MeSH terms

  • China
  • Electrophoresis, Capillary / methods
  • Hemoglobinopathies*
  • Hemoglobins / analysis
  • Hemoglobins, Abnormal* / analysis
  • Humans

Substances

  • Hemoglobins
  • Hemoglobins, Abnormal