Anticoagulation in adult patients supported with extracorporeal membrane oxygenation: guidance from the Scientific and Standardization Committees on Perioperative and Critical Care Haemostasis and Thrombosis of the International Society on Thrombosis and Haemostasis

J Thromb Haemost. 2023 Feb;21(2):373-396. doi: 10.1016/j.jtha.2022.11.014. Epub 2022 Dec 22.

Abstract

Anticoagulation of patients supported by extracorporeal membrane oxygenation is challenging because of a high risk of both bleeding and thrombotic complications, and often empirical. Practice in anticoagulation management is therefore highly variable. The scope of this guidance document is to provide clinicians with practical advice on the choice of an anticoagulant agent, dosing, and the optimal anticoagulant monitoring strategy during extracorporeal membrane oxygenation support in adult patients.

Keywords: anticoagulation; critical care; extracorporeal membrane oxygenation.

Publication types

  • Practice Guideline

MeSH terms

  • Adult
  • Anticoagulants / adverse effects
  • Blood Coagulation
  • Critical Care
  • Extracorporeal Membrane Oxygenation* / adverse effects
  • Heparin
  • Humans
  • Retrospective Studies
  • Thrombosis* / etiology
  • Thrombosis* / prevention & control

Substances

  • Anticoagulants
  • Heparin